147388-83-8

中文名称 3-甲基-5-[(2S)-1-甲基-2-吡咯烷基]异恶唑盐酸盐

英文名称 ABT-418 HYDROCHLORIDE

CAS 147388-83-8

分子式 C9H14N2O.ClH

分子量 202.684

MOL 文件 147388-83-8.mol

147388-83-8 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

中文别名

3-甲基-5-[(2S)-1-甲基-2-吡咯烷基]异恶唑盐酸盐

英文别名

ABT-418 HCl
ABT-418 HYDROCHLORIDE
(S)-3-Methyl-5-(1-methylpyrrolidin-2-yl)-isoxazolea€￠HCl
3-Methyl-5-[(2S)-1-Methylpyrrolidin-2-yl]isoxazole hydrochloride

物理化学性质

储存条件-20°C

溶解度H₂O: 15 mg/mL, soluble

形态solid

颜色white to off-white

稳定性自购买之日起 1 年内保持稳定。蒸馏水溶液可在 -20°C 下保存长达 3 个月。

安全数据

危险性符号(GHS)

GHS06

警示词危险

危险性描述H300+H310+H330

防范说明P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310

危险品标志T+

危险类别码26/27/28

安全说明22-28-36/37-45-7/9

危险品运输编号UN 2811 6.1/PG 1

WGK Germany3

常见问题列表

生物活性

ABT-418 hydrochloride 是一种高效、选择性的 nAChRs 激动剂，具有增强认知和抗焦虑的作用。ABT-418 hydrochloride 激活胆碱能通道，可用于阿尔茨海默病的研究。

靶点

nAChRs

体内研究

ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze.
Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment.
ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD.
ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression.

Animal Model:	Male SHRs (4–5 weeks old), attention deficit hyperactivity disorder (ADHD) model
Dosage:	0.6 mg/kg
Administration:	Intraperitoneal injection; once daily; for two weeks
Result:	Effectively improved spatial memory.