148439-49-0

中文名称 PRION PROTEIN (106-126) (HUMAN)

英文名称 H-LYS-THR-ASN-MET-LYS-HIS-MET-ALA-GLY-ALA-ALA-ALA-ALA-GLY-ALA-VAL-VAL-GLY-GLY-LEU-GLY-OH

CAS 148439-49-0

分子式 C80H138N26O24S2

分子量 1912.24

MOL 文件 148439-49-0.mol

更新日期 2024/07/09 16:44:17

148439-49-0 结构式

基本信息物理化学性质安全数据 PRION PROTEIN (106-126) (HUMAN)价格(试剂级) 常见问题列表

基本信息

中文别名

106-126-朊蛋白

英文别名

PRP (106-126)
PRP106-126, HUMAN
KTNMKHMAGAAAAGAVVGGLG
H-KTNMKHMAGAAAAGAWGGLG-OH
H-KTNMKHMAGAAAAGAVVGGLG-OH
106-126-Prion protein (human)
PRION PEPTIDE (106-126), HUMAN
PRION PROTEIN (106-126) (HUMAN)
PRION PROTEIN FRAGMENT 106-126 HUMAN
106-126-Prion protein PrP (synthetic)

物理化学性质

沸点2216.1±65.0 °C(Predicted)

密度1.283±0.06 g/cm3(Predicted)

储存条件−20°C

酸度系数(pKa)3.33±0.10(Predicted)

形态solid

颜色White to off-white

水溶解性Soluble to 1 mg/ml in water

安全数据

安全说明22-24/25

WGK Germany3

PRION PROTEIN (106-126) (HUMAN)价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-P0305	PRION PROTEIN (106-126) (HUMAN) PrP 106-126	148439-49-0	1mg	800元
2024/04/30	HY-P0305	PRION PROTEIN (106-126) (HUMAN) PrP 106-126	148439-49-0	5mg	2000元
2024/01/25	HY-P0305	PRION PROTEIN (106-126) (HUMAN) PrP 106-126	148439-49-0	500μg	900元

常见问题列表

生物活性

Prion Protein 106-126 (human) 是 Prion 的多肽片段，它可以诱导神经元凋亡，抗蛋白酶 K 消化，纤维形成，并介导正常细胞病毒蛋白 (PrPc) 转化为致病同工型 (PrPSc)。Prion Protein 106-126 (human) 通常用作研究朊病毒蛋白疾病中神经变性的模型。

体外研究

PrP (106-126) (100 μM) induces mTOR phosphorylation over time in N2a cells. PrP (106-126)-treated cells show significantly increased ROS production in comparison with that of PBS-treated control cells. Knockdown of PRAS40 enhances PrP (106-126)-induced apoptosis. PRAS40 alleviates PrP (106-126)-induced neuronal apoptosis via mTOR-AKT activation. PrP (106-126) interacts selectively with porcine brain endothelial cells (PBEC) via their luminal side, and causes cumulative cell death, as shown by lactate dehydrogenase release, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction, Caspase 3 induction and direct cell counting. In addition, PrP (106-126), but not its corresponding scrambled peptide, produces a 50% reduction of the trans-endothelial electrical resistance, while the PBEC maintained confluency.