148687-76-7
148687-76-7 结构式
基本信息
L-733,060 HYDROCHLORIDE
3-([3,5-BIS(TRIFLUOROMETHYL)PHENYL]METHOXY)-2-PHENYL-PIPERIDINE HYDROCHLORIDE
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-14406A | 3-([3,5-BIS(TRIFLUOROMETHYL)PHENYL]METHOXY)-2-PHENYL-PIPERIDINE HYDROCHLORIDE L-733060 hydrochloride | 148687-76-7 | 1 mg | 2600元 |
常见问题列表
|
NK1
|
L-733060 (30-300 nM) inhibits the [Ca
2+
]
i
mobilisation caused by substance P (100 nM) in a concentration-dependent manner in human tachykinin NK
1
receptor-transfected CHO cells.
L-733060 (2.5-20 μM; 48 and or 96 h) results in a concentration-dependent cytotoxicity in COLO 858 cells.
L-733060 (10-30 μM; 24 and 48 h) inhibits MEL H0 cells proliferation with IC
50
s of 27.5 μM and 18.9 μM at 24 h and 48 h, respectively.
L-733060 (20-50 μM; and or 72 h) inhibits COLO 679 cells growth with IC
50
s of 33.8 μM and 31.5 μM at 30 h and 72 h, respectively.
Cell Proliferation Assay
| Cell Line: | COLO 858 cells |
| Concentration: | 2.5, 5, 10, 20 μM |
| Incubation Time: | 0, 48, 96 h |
| Result: | Inhibited cells growth with IC 50 s of 8.7 μM and 7.1 μM at 48 h and 96 h, respectively. |
L-733060 (10-1000 μg/kg; i.v.) inhibits electrically stimulated plasma extravasation in dura mater of rats.
L-733060 (300-3000 μg/kg; i.v.) has no significant hypotensive or bradycardic effects are observed at doses of <3000 μg/kg in conscious or anaesthetised rats.
| Animal Model: | Male Sprague-Dawley rats (200 g) with electrical stimulation of the trigeminal ganglion |
| Dosage: | 10, 100, 1000 mg/kg |
| Administration: | I.v. injection |
| Result: | Produced a significant dose-related inhibition of plasma extravasation with an ID 50 of 212±19 μg/kg. |