1513879-21-4
中文名称
BQR695
英文名称
BQR695
CAS
1513879-21-4
分子式
C19H20N4O3
分子量
352.39
MOL 文件
1513879-21-4.mol
更新日期
2024/07/12 16:05:07
1513879-21-4 结构式
基本信息
中文别名
化合物BQR695 英文别名
BQR695NVP-BQR695
BQR695 - NVP-BQR695
BQR-695 (Synonyms: NVP-BQR695)
NVP-BQR-695
NVP-BQR 695
NVP-BQR695
Acetamide, 2-[[7-(3,4-dimethoxyphenyl)-2-quinoxalinyl]amino]-N-methyl-
所属类别
生物化工：激动剂抑制剂物理化学性质
沸点607.1±55.0 °C(Predicted)
密度1.250±0.06 g/cm3(Predicted)
储存条件Keep in dark place,Sealed in dry,2-8°C
溶解度DMSO:60.0(Max Conc. mg/mL);170.27(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);8.51(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);8.51(Max Conc. mM)
酸度系数(pKa)15.14±0.46(Predicted)
形态固体
颜色White to off-white
BQR695价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-18748 | BQR695 BQR-695 | 1513879-21-4 | 5mg | 800元 |
| 2024/08/19 | HY-18748 | BQR695 BQR-695 | 1513879-21-4 | 10mM * 1mLin DMSO | 880元 |
| 2024/08/19 | HY-18748 | BQR695 BQR-695 | 1513879-21-4 | 10mg | 1100元 |
常见问题列表
生物活性
BQR695 (NVP-BQR695)是PI4KIIIβ抑制剂，对人源PI4KIIIβ的IC50值约为90 nM。靶点
| Target | Value |
|
PI4KIIIβ
() | ~90 nM |
体外研究
Treatment with 0.5 μM of either KAI407 or BQR695 causes GFP-PH Osh2 to redistribute to the parasite plasma membrane, consistent with depletion of intracellular PI4P upon inhibition of PfPI4K function. BQR695 shows no evidence of toxicity against mature red blood cells (RBCs), induces a schizont-stage arrest indistinguishable from that observed in imidazopyrazine-treated parasites and exhibits cross-resistance with the imidazopyrazine-resistant lines.