151519-02-7
![151519-02-7 结构式](/CAS/GIF/151519-02-7.gif)
基本信息
2H-Pyran-2-one, 5-ethyl-5,6-dihydro-6-[(2R,3S,4R,5S,7E)-2-hydroxy-4-methoxy-3,5-dimethyl-7-nonen-1-yl]-, (5R,6R)-
物理化学性质
应用领域
以5-甲基-2-庚烯为原料经以下步骤合成:
水稻以100g/10公亩剂量处理水稻,对其地面部分抑制程度为18%~23%,以25g/10公亩剂量处理,则对地面部分几乎无抑制作用,在出穗前5~9d施用pironetin对产量无影响。小麦用125~1000mg/L的喷洒浓度处理旱田小麦,对株高呈现20%左右的生长抑制活性,但对小麦穗数并无影响。以2000mg/L处理对小麦有药害,平均每穗重及千粒重减少10%左右。
常见问题列表
雄小鼠急性经口 LD500325mg/kg。Ames试验呈阴性。
Microtubule
Pironetin (20-100 ng/mL; 24 hours; 3Y1 cells) treatment arrests the cell cycle progression at G2/M in 3Y1 cells.
Pironetin (1-10000 ng/mL; 3 days; HeLa, A2780 and K-NRK cells) treatment inhibits the cell proliferation.
IC
50
values against these cell lines are almost 10 ng/mL.
Cell Cycle Analysis
Cell Line: | 3Y1 cells |
Concentration: | 20 ng/mL, 50 ng/mL, 100 ng/mL |
Incubation Time: | 24 hours |
Result: | Arrested the cell cycle progression at G2/M in3Y1 cells. |
Cell Proliferation Assay
Cell Line: | HeLa, A2780 and K-NRK cells |
Concentration: | 1 ng/mL, 10 ng/mL, 100 ng/mL, 1000 ng/mL and 10000 ng/mL |
Incubation Time: | 3 days |
Result: | Inhibited the cell proliferation. |
Pironetin (0.78-6.25 mg/kg; intraperitoneal injection; daily; for 5 days; female CDF1-SLC mice) treatment shows a moderate antitumor effect, however, a severe weight loss is observed as a side effect.
Animal Model: | Female CDF1-SLC mice (10 weeks) injected with P388 murine leukemia cells |
Dosage: | 0.78 mg/kg, 1.56 mg/kg, 3.13 mg/kg, 6.25 mg/kg |
Administration: | Intraperitoneal injection; daily; for 5 days |
Result: | Showed a moderate antitumor effect. |