152831-36-2
152831-36-2 结构式
基本信息
中文别名
化合物NE 10790 英文别名
3-PEHPCNE 10790
NE 10790 (3-PEHPC)
FJVYPXVLXQXDHM-UHFFFAOYSA-N
NE 10790 (Synonyms: 3-PEHPC)
3-Pyridinepropanoic acid, α-hydroxy-α-phosphono-
2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoic acid
物理化学性质
沸点583.6±60.0 °C(Predicted)
密度1.724±0.06 g/cm3(Predicted)
储存条件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度Water:5.0(Max Conc. mg/mL);20.2(Max Conc. mM)
酸度系数(pKa)1.73±0.10(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
NE 10790 是法尼焦磷酸 (FPP) 合成酶的弱抑制剂，是有效的二磷酸利塞磷酸盐的磷酸酯类似物，也是一种弱的抗吸收剂。靶点
FPP synthase.
体外研究
NE 10790 inhibits incorporation of [ 14 C]mevalonic acid into Rab6, but not into H-Ras or Rap1, proteins that are modified by FTase and GGTase I, respectively. NE 10790 reduces viability in J774 cells. NE 10790 prevents prenylation of 22-26-kDa proteins that are not modified by FTase or GGTase I.