153322-06-6
中文名称
ARL15896; ARL 15896; LANICEMINE HYDROCHLORIDE; AR-R15896AR
英文名称
Lanicemine dihydrochloride
CAS
153322-06-6
分子式
C13H16Cl2N2
分子量
234.73
MOL 文件
153322-06-6.mol
153322-06-6 结构式
基本信息
中文别名
拉尼西明二盐酸盐 英文别名
AZD6765ARL-15896
Lanicemine 2HCl
AZD6765 dihydrochloride
Lanicemine hydrochloride
FPL 15896 dihydrochloride
Lanicemine dihydrochloride
AR-R 15896 dihydrochloride
AZD6765 dihydrochloride >=97% (HPLC)
(αS)-α-Phenyl-2-pyridineethanamine dihydrochloride
ARL15896; ARL 15896; LANICEMINE HYDROCHLORIDE; AR-R15896AR价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-108235A | ARL15896; ARL 15896; LANICEMINE HYDROCHLORIDE; AR-R15896AR Lanicemine dihydrochloride | 153322-06-6 | 5mg | 600元 |
| 2024/11/08 | HY-108235A | ARL15896; ARL 15896; LANICEMINE HYDROCHLORIDE; AR-R15896AR Lanicemine dihydrochloride | 153322-06-6 | 10mM * 1mLin DMSO | 660元 |
| 2024/11/08 | HY-108235A | ARL15896; ARL 15896; LANICEMINE HYDROCHLORIDE; AR-R15896AR Lanicemine dihydrochloride | 153322-06-6 | 10mg | 1050元 |
常见问题列表
生物活性
Lanicemine (AZD6765) dihydrochloride 是一种低捕获的 NMDA 受体拮抗剂，Ki 为 0.56-2.1 μM。CHO 和爪蟾卵母细胞中，IC50 分别为 4-7 μM 和 6.4 μM。具有抗抑郁作用。靶点
NMDA receptor
体内研究
Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine.
| Animal Model: | Male Sprague-Dawley rats |
| Dosage: | 3, 10 or 30 mg/kg |
| Administration: | Intraperitoneal |
| Result: | Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity. |