1533426-72-0
中文名称
SCR7
英文名称
SCR7
CAS
1533426-72-0
分子式
C18H14N4OS
分子量
334.4
MOL 文件
1533426-72-0.mol
更新日期
2024/05/20 09:19:55
1533426-72-0 结构式
基本信息
中文别名
2,3-二氢-5,6-二[(E)-(苯基亚甲基)氨基]-2-硫代-4(1H)-嘧啶酮 英文别名
SCR7CS-1733
SCR7 USP/EP/BP
5,6-bis((E)-benzylideneamino)-2-mercaptopyrimidin-4-ol
5,6-bis((E)-benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
2,3-Dihydro-5,6-bis[(E)-(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone
4(1H)-Pyrimidinone, 2,3-dihydro-5,6-bis[(E)-(phenylmethylene)amino]-2-thioxo-
所属类别
生物化工：DNA/RNA Synthesis 抑制剂物理化学性质
熔点206-208°C
密度1.27±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度可溶于DMSO（少许）、甲醇（少许）
酸度系数(pKa)7.93±0.25(Predicted)
形态固体
颜色淡黄色
常见问题列表
生物活性
SCR7 是一种特异性 DNA Ligase IV 抑制剂，其阻断非同源性末端连接(NHEJ)。体外研究
SCR7 effectively inhibits the formation of multimers at 200 μM and above. SCR7 successfully inhibits cell proliferation of MCF7, A549, HeLa, T47D, A2780, HT1080, and Nalm6 with IC50 of 40, 34, 44, 8.5, 120, 10, and 50 μM, respectively. SCR7 suppresses the NHEJ repair of CRISPR-Cas9-induced DSBs.体内研究
SCR7 treatment (10 mg/kg, i.m.) significantly reduces breast adenocarcinoma-induced tumor, and exhibits 4-fold increase in lifespan compared with control group. However, in Swiss albino mice with Dalton’s lymphoma tumor model, SCR7 (20 mg/kg, i.p.) exhibits neither tumor regression nor increase in lifespan. In BALB/c mice, SCR7 (20 mg/kg, i.p.) significantly enhances the cytotoxic effects of radiation, etoposide and 3-Aminobenzamide on tumor derived from Dalton’s lymphoma (DLA) cells.