154563-54-9

中文名称 N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide

英文名称 N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide

CAS 154563-54-9

分子式 C14H5ClF9N3O

分子量 437.65

MOL 文件 154563-54-9.mol

更新日期 2023/03/20 15:41:27

154563-54-9 结构式

基本信息物理化学性质图谱信息常见问题列表

基本信息

中文别名

化合物 T24816
化合物SP-100030

英文别名

SP 100030
N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide
5-Pyrimidinecarboxamide, N-[3,5-bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-

物理化学性质

熔点166-167 °C

沸点340.6±42.0 °C(Predicted)

密度1.637±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度溶于二甲基亚砜

酸度系数(pKa)8.97±0.70(Predicted)

形态Solid

颜色Off-white to light yellow

图谱信息

N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide(154563-54-9)核磁图(¹HNMR)

常见问题列表

生物活性

SP-100030 是一种有效的 NF-κB 和激活蛋白-1 (AP-1) 双抑制剂 (IC50 分别为 50 和 50 nM)。SP-10003 抑制 Jurkat和其他T细胞系产生的 IL-2、IL-8 和 TNF-α 的产生。SP-100030 降低小鼠胶原性关节炎 (CIA)。

体外研究

SP-100030 blocks the production of IL-2 and IL-8 in Jurkat T-cells at the same concentrations as seen in the luciferase assay (IC ₅₀ ≈30 nM).
ELISA and RT-PCR confirmed that IL-2, IL-8, and TNF-alpha production by activated Jurkat and other T cell lines were inhibited by SP100030.

体内研究

SP100030 (10 mg/kg/day; i.p.; day 21 to day 34) significantly decreased arthritis severity.

Animal Model:	Six- to 8-wk-old male DBA/1J mice (immunized with type II collagen)
Dosage:	10 mg/kg
Administration:	I.p.; daily, starting at day 21 to the end of the study on day 34
Result:	Significantly decreased arthritis scores compared with controls; Histologic evaluation of the paws from mice treated from day 20 to 34 showed a trend toward decreased inflammation.