157124-84-0
中文名称
1-phosphono-4-(3-phenoxyphenyl) butylsulfonic acid tripotassiuM salt
英文名称
1-phosphono-4-(3-phenoxyphenyl) butylsulfonic acid tripotassiuM salt
CAS
157124-84-0
分子式
C16H16K3O7PS
分子量
500.628
MOL 文件
157124-84-0.mol
157124-84-0 结构式
基本信息
中文别名
化合物 T10587 英文别名
BPH-652BPH 652,BPH652
FIOQVVKPUBNHEM-UHFFFAOYSA-N
1-phosphono-4-(3-phenoxyphenyl) butylsulfonic acid tripotassiuM salt
物理化学性质
储存条件4°C, away from moisture
形态Solid
颜色White to off-white
水溶解性Water : 25 mg/mL (49.94 mM; Need ultrasonic)
常见问题列表
生物活性
BPH-652 是 CrtM 的抑制剂，Ki 值为 1.5 nM，IC50 值为100-300 nM (S. aureus 色素形成)。靶点
Ki: 1.5 nM (CrtM).
IC50: 100-300 nM (
S. aureus
pigment formation).
体内研究
BPH-652 treatment (0.5 mg twice per day (days −1, 0, 1, and 2), Intraperitoneal injection) significantly lowers S. aureus bacterial counts in the kidneys of the mice than those of the control group (P < 0.001), with 8 of 13 below the detection threshold, versus only 2 of 14 in the control group; on average, this result corresponds to a 98% decrease in surviving bacteria in the treatment group.
| Animal Model: | A systemic S. aureus infection model in mice. |
| Dosage: | 0.5 mg twice per day (days −1, 0, 1, and 2). |
| Administration: | Intraperitoneal injection. |
| Result: | S. aureus bacterial counts in the kidneys of the mice treated with BPH-652 were significantly lower than those of the control group. |