1578153-27-1
中文名称
RO6889678
英文名称
RO6889678
CAS
1578153-27-1
分子式
C21H20ClFN4O5S
分子量
494.92
MOL 文件
1578153-27-1.mol
1578153-27-1 结构式
基本信息
中文别名
化合物RO6889678 英文别名
RO68896783-Morpholinecarboxylic acid, 4-[[(6R)-6-(2-chloro-4-fluorophenyl)-3,6-dihydro-5-(methoxycarbonyl)-2-(2-thiazolyl)-4-pyrimidinyl]methyl]-, (3S)-
应用领域
用途一
RO6889678 is an inhibitor of HBV with a complex ADME profile. RO6889678 showed an intracellular enrichment of 78-fold in hepatocytes, with an apparent intrinsic clearance of 5.2 μl/min per mg protein and uptake and biliary clearances of 2.6 and 1.6 μl/min per mg protein, respectively. The induction potential of RO6889678 on cytochrome P450 (P450) enzymes and transporters at steady state was assessed and cotreatment with ritonavir revealed a complex drug-drug interaction with concurrent P450 inhibition and moderate UDP-glucuronosyltransferase induction.