158364-59-1
中文名称
158364-59-1
英文名称
Carbamic acid,N-[2-[[(2,3-dimethylimidazo[1,2-a]pyridin-8-yl)amino]methyl]-3-methylphenyl]-,methyl ester
CAS
158364-59-1
分子式
C19H22N4O2
分子量
338.4
MOL 文件
158364-59-1.mol
158364-59-1 结构式
基本信息
中文别名
普马拉唑化合物 T16682
英文别名
PUMAPRAZOLECarbamic acid,N-[2-[[(2,3-dimethylimidazo[1,2-a]pyridin-8-yl)amino]methyl]-3-methylphenyl]-,methyl ester
所属类别
生物：拮抗剂物理化学性质
密度1.21±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)13.67±0.70(Predicted)
形态Solid
颜色Light yellow to yellow
158364-59-1价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-19223 | 普马拉唑 Pumaprazole | 158364-59-1 | 5mg | 2500元 |
| 2025/02/08 | HY-19223 | 158364-59-1 Pumaprazole | 158364-59-1 | 10 mM * 1 mLin DMSO | 2750元 |
| 2025/02/08 | HY-19223 | 普马拉唑 Pumaprazole | 158364-59-1 | 10mg | 4000元 |
常见问题列表
生物活性
Pumaprazole 是一种可逆性质子泵拮抗剂。靶点
proton pump
体内研究
Pumaprazole is a reversible proton pump antagonist. Basal acid secretion in the Ghosh-Schild rat is inhibited by Pumaprazole with a higher efficacy compare to ranitidine. Pumaprazole displays identical ID 50 values on day 1 (11 μmol/kg, 95% confidence limits of 5 and 23) and on day 7 (10 μmol/kg, 95% confidence limits of 4 and 23) of a repeated dose study in this model. The lower dose of Pumaprazole (27 μmol/kg) rapidly elevates luminal pH up to almost neutrality, the higher dose (54 μmol/kg) further prolongs this pH-elevating effect.