158959-32-1
158959-32-1 结构式
基本信息
中文别名
化合物 T12860 英文别名
SC57666Benzene, 1-fluoro-4-[2-[4-(methylsulfonyl)phenyl]-1-cyclopenten-1-yl]-
物理化学性质
熔点146-147 °C
沸点472.1±45.0 °C(Predicted)
密度1.253±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: ≥ 100 mg/mL (316.07 mM)
形态Solid
颜色White to off-white
158959-32-1价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-U00129 | 158959-32-1 SC57666 | 158959-32-1 | 5mg | 5800元 |
| 2024/04/30 | HY-U00129 | 158959-32-1 SC57666 | 158959-32-1 | 10mM * 1mLin DMSO | 6380元 |
| 2024/04/30 | HY-U00129 | 158959-32-1 SC57666 | 158959-32-1 | 10mg | 9500元 |
常见问题列表
生物活性
SC57666是选择性的 COX2 抑制剂，IC50 值为26 nM。靶点
|
COX-2 26 nM (IC 50 ) |
体外研究
SC57666 inhibits COX2 with an IC 50 of 3.2±0.8 nM in CHO cells stably transfected with human COX isozymes, with 1000 fold or more selectivity over COX1 (IC 50 =6000±1900 nM).
体内研究
SC57666 has been shown to be orally active (ED 50 =1.7 mpk) in the adjuvant-induced arthritis model. No gastric lesions are observed in mice after 5 h when SC57666 is administered intragastrically at 600 mpk. No intestinal damage is observed in rats after 72 h when SC57666 is administered intragastrically at 200 mpk.