160385-86-4
中文名称
NORBIOTINAMINE HYDROCHLORIDE
CAS
160385-86-4
分子式
C10H18ClN3O2S
分子量
279.79
MOL 文件
160385-86-4.mol
160385-86-4 结构式
常见问题列表
生物活性
Norbiotinamine hydrochloride 是生物素的一种替代物。Norbiotinamine 可与氨基酸的羧基偶联得到具有反向连接的酰胺键的反向肽。体外研究
In order to couple biotin to amino acids, reaction has to be with an amino group. An example is biocytin (biotin lysine). However, Norbiotinamine could be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction. As an example, Norbiotinamine is coupled with the NHS ester of N-Boc-glutamic acid γ-benzyl ester. The resulting norbiotinylamide of γglutamic acid (VII), obtained after deprotection, is similar to biocytin, but it has a shorter aliphatic chain and an inverted amide bond.