160928-38-1
中文名称
6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物
CAS
160928-38-1
分子式
C15H24Br2N5O12P3
分子量
719.11
MOL 文件
160928-38-1.mol
更新日期
2023/03/20 15:41:20
160928-38-1 结构式
基本信息
中文别名
6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物 英文别名
ARL-67156FPL-67156
FPL 67156 TRISODIUM
ARL 67156 TRISODIUM
ARL 67156 TRISODIUM SALT
ARL 67156 trisodium salt hydrate
6-N,N-Diethyl-D-b,g-dibromomethyleneATP
6-N,N-Diethyl-D-B,G-Dibromomethyleneatp Tri
6-N,N-DIETHYL-D-BETA-GAMMA-DIBROMOMETHYLENE ATP
6-N,N-Diethyl-D-β,γ-dibromomethyleneATPtrisodiumsalt
物理化学性质
沸点879.6±75.0 °C(Predicted)
密度2.32±0.1 g/cm3(Predicted)
储存条件−20°C
溶解度H2O: 10 mg/mL
酸度系数(pKa)0.82±0.50(Predicted)
形态solid
颜色off-white
6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-103265B | 6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物 ARL67156 trisodium salt hydrate | 160928-38-1 | 1mg | 1800元 |
| 2024/04/30 | HY-103265 | 6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物 ARL67156 trisodium salt | 160928-38-1 | 1mg | 1800元 |
| 2024/04/30 | HY-103265B | 6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物 ARL67156 trisodium salt hydrate | 160928-38-1 | 5mg | 6500元 |
常见问题列表
生物活性
ARL67156 trisodium salt hydrate 是一种 ecto-ATPase 抑制剂。ARL67156 trisodium salt hydrate 是弱的竞争性 NTPDase1 (CD39)，NTPDase3 和 NPP1 抑制剂，Ki 分别为 11，18 和 12 μM。ARL67156 trisodium salt hydrate 可预防体内主动脉瓣钙化。靶点
Ki: 11 μM (NTPDase1), 18 μM (NTPDase3), 12 μM (NPP1)
体外研究
ARL67156 trisodium salt is also an effective inhibitor of UTP breakdown by superior cervical ganglion cells and to potentiate contractions elicited by this nucleotide in isolated tail artery of rat. ARL67156 is not an effective inhibitor of NTPDase2, NTPDase8, NPP3 and ecto-5′-nucleotidase (CD73), although it also reduces the activity of these enzymes.
体内研究
Pre-treatment of mice with ARL67156 (2 mg/kg, i.p.), a selective inhibitor of CD39 (CD39i), completely prevents the increase of serum adenosine concentration induced by Fructose 1,6-bisphosphate (FBP; 100 mg/kg).
| Animal Model: | C57BL/6 mice |
| Dosage: | 2 mg/kg |
| Administration: | Pre-treated (i.p.) 1 h before administration of FBP (100 mg/kg) |
| Result: | Completely prevented the increase of serum adenosine concentration induced by FBP. |