1613509-49-1
中文名称
2-环丁基-10-甲基-3-苯基嘧啶并[4,5-B]喹啉-4,5(3H,10H)-二酮
英文名称
Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl-
CAS
1613509-49-1
分子式
C22H19N3O2
分子量
357.41
MOL 文件
1613509-49-1.mol
1613509-49-1 结构式
基本信息
中文别名
2-环丁基-10-甲基-3-苯基嘧啶并[4,5-B]喹啉-4,5(3H,10H)-二酮 英文别名
Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclobutyl-10-methyl-3-phenyl-物理化学性质
沸点495.3±55.0 °C(Predicted)
密度1.35±0.1 g/cm3(Predicted)
酸度系数(pKa)2.41±0.20(Predicted)
形态Solid
颜色Light yellow to yellow
应用领域
用途一
SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion. SRI-41315 induce a prolonged pause at stop codons and suppress PTCs associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity.