161922-40-3
中文名称
盐酸阿西维辛
英文名称
Acivicin hydrochloride
CAS
161922-40-3
分子式
C5H8Cl2N2O3
分子量
215.03
MOL 文件
161922-40-3.mol
161922-40-3 结构式
常见问题列表
生物活性
Acivicin hydrochloride (AT-125 hydrochloride) 是一种由猪链霉菌产生的天然产物，是 γ-谷氨酰转肽酶 (GGT) 抑制剂。Acivicin hydrochloride 可以透过血脑屏障，并具有抗癌，抗寄生虫的特性。靶点
γ-glutamyl transpeptidase
体外研究
Acivicin hydrochloride (AT-125 hydrochloride; 0.1-50 μM; 5 days) has an IC 50 of 0.7 μM in human HepG2 cells.
体内研究
Acivicin hydrochloride (AT-125 hydrochloride; 5 mg/kg; IP; twice weekly) reduces urinary γ-GT by 70-78%.
| Animal Model: | Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene |
| Dosage: | 5 mg/kg |
| Administration: | IP; twice weekly (monday and wednesday) |
| Result: | Reduced urinary γ-GT by 70-78%. |