1621175-65-2

中文名称 CS-2374

英文名称 GPR39-C3

CAS 1621175-65-2

分子式 C18H19ClN6O2S

分子量 418.9

MOL 文件 1621175-65-2.mol

更新日期 2024/08/28 10:39:23

1621175-65-2 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

中文别名

化合物TC-G-1008
16211175-65-2

英文别名

CS-2374
GPR39-C3
TC-G-1008
GPR39C3
GPR39 C3
TC-G-1008 (GPR39-C3)
N-[3-Chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide
N-(3-Chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide
Methanesulfonamide, N-[3-chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]-

所属类别

生物化工：激动剂抑制剂

物理化学性质

沸点662.1±65.0 °C(Predicted)

密度1.462±0.06 g/cm3(Predicted)

储存条件2-8°C

储存条件Sealed in dry,2-8°C

溶解度DMSO:63.97(Max Conc. mg/mL);152.72(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:5):0.16(Max Conc. mg/mL);0.38(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);4.77(Max Conc. mM)

酸度系数(pKa)7.43±0.10(Predicted)

形态结晶固体

颜色White to off-white

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H302-H315-H319-H335

防范说明P261-P280-P301+P312-P302+P352-P305+P351+P338

常见问题列表

生物活性

TC-G-1008（GPR39-C3）是一种有效的、口服活性的 G-protein coupled receptor 39 (GPR39)(zinc receptor) 激动剂，对大鼠受体和人类受体的EC50值分别为0.4 nM 和0.8 nM。

靶点

Target	Value
rGPR39 (Cell-free assay)	0.4 nM(EC50)
hGPR39 (Cell-free assay)	0.8 nM(EC50)

体外研究

TC-G-1008 shows selectivity over a panel of kinases (IC ₅₀ s>10 μM) and does not exhibit relevant binding affinity for the related ghrelin and neurotensin-1 receptors (IC ₅₀ s>30 μM). In HEK293-GPR39 cells, GPR39-C3, which is a positive allosteric modulator, activates cAMP production (downstream of Gs), IP1 accumulation (downstream of Gq), SRF-RE-dependent transcription (downstream of G12/13), and β-arrestin recruitment. GPR39-C3 induces dose- and time-dependent loss of response in cAMP production by second challenge of the compound.

体内研究

Rat and mouse plasma protein binding for TC-G-1008 is measured as 99.3% and 99.1%, respectively. TC-G-1008 is orally bioavailable in mice and robustly induces acute GLP-1 levels. Upon single oral doses of 10, 30, and 100 mg/kg of aqueous suspensions in 0.5% methylcellulose/0.1% Tween 80, TC-G-1008 achieves, between 1 and 1.5 h, maximal exposures of 1.4, 6.1, and 25.3 μM, respectively.