162763-53-3
中文名称
ABT-719;ABT 719;ABT719;A-86719.1
英文名称
4H-Quinolizine-3-carboxylicacid, 8-[(3S)-3-amino-1-pyrrolidinyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-,hydrochloride (1:1)
CAS
162763-53-3
分子式
C18H21ClFN3O3
分子量
381.83
MOL 文件
162763-53-3.mol
![162763-53-3 结构式](/CAS/20211123/GIF/162763-53-3.gif)
基本信息
中文别名
化合物 T29531 英文别名
A-86719.1A-816719.1
A 816719.1
ABT-719 HCl
ABT-719 hydrochloride
ABT-719
ABT 719
ABT719
A-86719.1
4H-Quinolizine-3-carboxylicacid, 8-[(3S)-3-amino-1-pyrrolidinyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-,hydrochloride (1:1)
应用领域
用途一
ABT-719 is a 2-pyridone antimicrobial with activity against enterococci, Escherichia coli, and Pseudomonas aeruginosa in experimental murine pyelonephritis. Therapeutic ED50s for ABT-719 against these infections were equal to or up to ten-fold lower than those for ciprofloxacin, used as a reference because of similarity in mode of action. Against E. faecalis, the therapeutic ED50s for ABT-719 were 4.5-13.6 mg/kg.day for sc administration and 6.8-8.9 mg/kg.day for oral administration. ABT-719 was more potent than ciprofloxacin and vancomycin against the E. faecalis strains, which showed ciprofloxacin and vancomycin resistance covering a range of MICs.