1639933-78-0
中文名称
LolCDE-IN-1
英文名称
LolCDE-IN-1
CAS
1639933-78-0
分子式
C21H16FN3O
分子量
345.37
MOL 文件
1639933-78-0.mol
更新日期
2024/09/03 11:45:26
1639933-78-0 结构式
基本信息
中文别名
化合物LOLCDE-IN-1 英文别名
LolCDE-IN-1Pyridine, 4-[3-[3-[(4-fluorophenyl)methoxy]phenyl]-1H-pyrazol-4-yl]-
物理化学性质
沸点529.9±50.0 °C(Predicted)
密度1.261±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 41.67 mg/mL (120.65 mM)
酸度系数(pKa)10.76±0.50(Predicted)
形态Solid
颜色Light yellow to yellow
常见问题列表
生物活性
LolCDE-IN-1 是一种 LolCDE 复合物的抑制剂，具有抗菌活性。靶点
Bacterial
体外研究
LolCDE-IN-1 (compound 2) inhibits the function of the LolCDE complex, which is required for transport of lipoproteins to the outer membrane.
LolCDE-IN-1 inhibits E. coli ATCC 25922 and E. coli ATCC 25922 ΔtolCwith MIC with 8 μg/ml and 0.125 μg/ml.
LolCDE-IN-1 inhibits bacterial growth by targeting LolCDE to block lipoprotein transport to the outer membrane.