166038-00-2
中文名称
S-4-bromobenzylglutathione cyclopentyl diester
英文名称
S-4-bromobenzylglutathione cyclopentyl diester
CAS
166038-00-2
分子式
C27H38BrN3O6S
分子量
612.58
MOL 文件
166038-00-2.mol
更新日期
2023/03/20 15:41:27
166038-00-2 结构式
基本信息
中文别名
S-P-溴苄基谷胱甘肽环戊基二酯 英文别名
BrBzGCp2S-p-Bromobenzylglutathione cyclopentyl diester
S-4-bromobenzylglutathione cyclopentyl diester
S-p-Bromobenzylglutathione cyclopentyl diester >=98% (HPLC)
Glycine, N-[S-[(4-bromophenyl)methyl]-N-L-γ-glutamyl-L-cysteinyl]-, dicyclopentyl ester (9CI)
物理化学性质
沸点790.6±60.0 °C(Predicted)
密度1.38±0.1 g/cm3(Predicted)
储存条件2-8°C
溶解度DMSO: 250 mg/mL (408.11 mM)
酸度系数(pKa)12.84±0.46(Predicted)
形态粉末
颜色白色至米色
S-4-bromobenzylglutathione cyclopentyl diester价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-136684 | S-4-bromobenzylglutathione cyclopentyl diester BrBzGCp2 | 166038-00-2 | 5mg | 800元 |
| 2024/11/08 | HY-136684 | S-4-bromobenzylglutathione cyclopentyl diester BrBzGCp2 | 166038-00-2 | 10mM * 1mLin DMSO | 1080元 |
| 2024/11/08 | HY-136684 | S-4-bromobenzylglutathione cyclopentyl diester BrBzGCp2 | 166038-00-2 | 10mg | 1400元 |
常见问题列表
生物活性
BrBzGCp2 是乙二醛酶 1 (GLO1) 的抑制剂，其 GC50 为 4.23 μM (HL-60 细胞)。BrBzGCp2 具有抗肿瘤和神经保护活性。靶点
GC50: 4.23 μM (GLO1).
体内研究
GLO1 inhibition by BrBzGCp2 increases center time in the OF test, without changing distance traveled. GLO1 inhibition increases MG (methylglyoxal) concentration, thus reducing anxiety-like behavior.
BrBzGCp2 pre-treatment decreases seizure duration.
BrBzGCp2 injection alleviates the level of anxiety in mice, and mice with less anxiety and fear were more likely to explore the unknown area, implying that inhibition of GLO1 activity mitigated anxiety levels.
BrBzGCp2 treatment restores the VPA-induced inhibition effect on GABA
A
receptor activation.
BrBzGCp2 significantly lowers the blood pressure and ameliorated endothelial dysfunction in diabetic mice.
| Animal Model: | Male CD-1 mice. |
| Dosage: | 50 mg/kg. |
| Administration: | IP once (Two hours post-injection, mice were sacrificed, and brains were rapidly dissected and flash-frozen on dry ice. MG concentration was measured) |
| Result: | Allowed MG levels to accumulate for 2 hours |