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166526-99-4

中文名称 3-羟基阿戈美拉汀D3
英文名称 3-Hydroxy Agomelatine
CAS 166526-99-4
分子式 C15H17NO3
分子量 259.3
MOL 文件 166526-99-4.mol
更新日期 2023/03/20 15:41:19
166526-99-4 结构式 166526-99-4 结构式

基本信息

中文别名
3-羟基阿戈美拉汀
英文别名
3-Hydroxy Agomelatine
Agomelatine 3-Hydroxy Impurity
N-[2-(7-methoxy-3-hydroxynaphth-1-yl)ethyl]-acetamide
N-(2-(3-Hydroxy-7-methoxynaphthalen-1-yl)ethyl)acetamide
Acetamide, N-[2-(3-hydroxy-7-methoxy-1-naphthalenyl)ethyl]-
Agomelatine impurity 1/3-Hydroxy Agomelatine/N-[2-(3-Hydroxy-7-methoxy-1-naphthalenyl)ethyl]acetamide
所属类别
分析化学：药典标准品和杂质标准品

物理化学性质

沸点545.8±40.0 °C(Predicted)
密度1.190±0.06 g/cm3(Predicted)
储存条件-20°C储存
酸度系数(pKa)9.85±0.40(Predicted)
形态Solid
颜色Off-white to light brown

常见问题列表

生物活性
3-Hydroxy agomelatine 是 Agomelatine 的代谢产物。3-Hydroxy agomelatine 是 5-HT2C 受体拮抗剂，IC50 为 3.2 μM，Ki 为 1.8 μM。
靶点

5-HT 2C Receptor

3.2 μM (IC 50 )

5-HT 2C Receptor

1.8 μM (Ki)

体外研究

Agomelatine and S 21517 have moderately high affinities for 5-HT 2C receptors ( K i = 0.21 μM and 0.13 μM, respectively). The metabolite 3-Hydroxy agomelatine (S 21540) has a 10-fold lower affinity ( K i = 1.8 μM). Agomelatine, S 21517 and 3-Hydroxy agomelatine (10 -7 -10 -4 M) are antagonists at 5-HT 2C receptors, with a rank order of efficacy as follows: S 21517>Agomelatine>3-Hydroxy agomelatine.

体内研究

Increasing doses (from 1.25 to 40 mg/kg, intraperitoneal injection) of 3-Hydroxy agomelatine (S 21540) does not affect the penile erections induced by mCPP and Ro 60-0175 in Wistar rat.

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