16662-46-7
中文名称
METHOXYVERAPAMIL HYDROCHLORIDE
英文名称
METHOXYVERAPAMIL HYDROCHLORIDE
CAS
16662-46-7
分子式
C28H41ClN2O5
分子量
521.09
MOL 文件
16662-46-7.mol
更新日期
2023/03/20 15:41:24
16662-46-7 结构式
基本信息
中文别名
盐酸戈洛帕米 英文别名
D600D600, HCL
GALLOPAMIL
GALLOPAMIL HCL
(S)-Gallopamil
D 600 HYDROCHLORIDE
GALLOPAMIL HYDROCHLORIDE
(+/-)-METHOXYVERAPAMIL HCL
METHOXYVERAPAMIL HYDROCHLORIDE
(+/-)-METHOXYVERAPAMIL, HYDROCHLORIDE
物理化学性质
熔点145-148°
储存条件-20°C储存
溶解度DMF: 16.7 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 0.25 mg/ml
形态结晶固体
颜色White to off-white
常见问题列表
生物活性
Gallopamil hydrochloride (Methoxyverapamil hydrochloride) 是一种维拉帕米的甲氧基衍生物 (methoxy derivative of verapamil)，也是一种苯基烷基胺钙 (phenylalkylamine calcium) 拮抗剂。Gallopamil hydrochloride 以浓度依赖性方式抑制酸分泌，IC50 为 10.9 μM。Gallopamil hydrochloride 是一种有效的抗心律不齐和血管扩张剂。靶点
|
Ca 2+
|
体内研究
Gallopamil hydrochloride (Methoxyverapamil hydrochloride; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate.
| Animal Model: | Male Wistar rats weighing 290-370 g |
| Dosage: | 0.2 mg/kg |
| Administration: | i.v.; 5 min |
| Result: | Markedly reduced VT and totally prevented VF. |