166974-23-8
中文名称
166974-23-8
英文名称
sodium 4,6-dichloro-3-[(E)-(2-oxo-1-phenyl-pyrrolidin-3-ylidene)methyl]-1H-indole-2-carboxylate
CAS
166974-23-8
分子式
C20H13Cl2N2NaO3
分子量
425.24
MOL 文件
166974-23-8.mol
166974-23-8 结构式
基本信息
中文别名
化合物 T11516 英文别名
sodium 4,6-dichloro-3-[(E)-(2-oxo-1-phenyl-pyrrolidin-3-ylidene)methyl]-1H-indole-2-carboxylate常见问题列表
生物活性
GV-196771A 是 GV196771 的钠盐形式。是 NMDA 受体拮抗剂。靶点
NMDA receptor
体内研究
GV196771 is a potent antagonist of the modulatory glycine site of the N-methyl-D-aspartate receptor. GV196771 is a potent antagonist of the modulatory glycine site of the NMDA receptor developed for treatment of neuropathic pain. GV196771 is an NMDA receptor antagonist with low oral bioavailability in rats and mice. GV196771 has low oral bioavailability (<10%) and plasma clearance (~2 mL/min/kg) in rats.