16722-44-4
英文名称
3-Quinolinamine,N-(2-quinolinylmethylene)-
CAS
16722-44-4
分子式
C19H13N3
分子量
283.33
MOL 文件
16722-44-4.mol
16722-44-4 结构式
应用领域
用途一
JJO-1 is a bi-quinoline that allosterically activates all AMPK αβγ isoforms in vitro except complexes containing the γ3 subunit. JJO-1 does not directly activate the autoinhibited α subunit kinase domain and differs among other known direct activators of AMPK in that allosteric activation occurs only at low ATP concentrations, and is not influenced by either mutation of the γ subunit adenylate-nucleotide binding sites or deletion of the β subunit carbohydrate-binding module.