168649-23-8
中文名称
5-(2-苯基)-吲哚-3-乙酸
英文名称
1H-Indole-3-acetic acid, 5-phenyl-
CAS
168649-23-8
分子式
C16H13NO2
分子量
251.28
MOL 文件
168649-23-8.mol
更新日期
2024/10/11 23:04:01
168649-23-8 结构式
基本信息
中文别名
化合物5-PH-IAA5-苯基-1H-吲哚-3-乙酸
5-(2-苯基)-吲哚-3-乙酸
英文别名
5-Ph-IAA5-(2-phenyl)-indole-3-acetic acid
1H-Indole-3-acetic acid, 5-phenyl-
所属类别
医药中间体:原料药中间体物理化学性质
沸点521.3±35.0 °C(Predicted)
密度1.291±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 125 mg/mL (497.45 mM)
酸度系数(pKa)4.47±0.30(Predicted)
形态固体
颜色White to off-white
常见问题列表
生物活性
5-Ph-IAA 是 IAA 的衍生物。5-Ph-IAA 是一种配体与 OsTIR1 (F74G) 突变体一起建立了生长素诱导的 degron 2 系统 (AID2)。AID2 诱导 mAID 融合蛋白的快速有效消耗,从而研究活细胞中的蛋白功能。AID2 可以抑制肿瘤。体外研究
HCT116 cells constitutively expressing OsTIR1(F74G) are exposed to 5-Ph-IAA (1 µM; 6 hours), leading to DHC1-mAC degradation, which means the AID2 system better than the original AID system in generating conditional mutant cell lines.
Western Blot Analysis
Cell Line: | HCT116 cells |
Concentration: | 1 µM |
Incubation Time: | 6 hours |
Result: | Depleted DHC1-mAC efficiently in HCT116 cells constitutively expressing OsTIR1(F74G). |
体内研究
5-Ph-IAA (0-10 mg/kg; intraperitoneally injection; every day; 7 days), used for the AID2 system ,is sufficient to deplete mAID-BRD4 and TOP2A-mAC, leading to tumour suppression.
Animal Model: | Balb/c-nu female mice (7 weeks old; 16–20 g ) bearing mAID-BRD4 and TOP2A-mAC xenograft tumours cells |
Dosage: | 0 mg/kg, 1 mg/kg, 3 mg/kg and 10 mg/kg |
Administration: | Intraperitoneally injection; every day; 7 days |
Result: | Displayed significant tumour suppression of mAID-BRD4 xenografts and TOP2A-mAC xenografts. |