169105-89-9
中文名称
(3R,4R,5R)-5-(羟基甲基)哌啶-3,4-二醇盐酸盐
英文名称
ISOFAGOMINE, HYDROCHLORIDE
CAS
169105-89-9
分子式
C6H14ClNO3
分子量
183.63
MOL 文件
169105-89-9.mol
169105-89-9 结构式
基本信息
中文别名
异桑叶生物碱(3R,4R,5R)-5-(羟基甲基)哌啶-3,4-二醇
(3R,4R,5R)-5-(羟基甲基)哌啶-3,4-二醇盐酸盐
英文别名
AfegostatD-Isofagomine
Unii-G23ap190ys
IsofagomineHydrochlroide
ISOFAGOMINE, HYDROCHLORIDE
5-Hydroxymethyl-3,4-piperidinediol
(3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol
3,4-Piperidinediol, 5-(hydroxymethyl)-, (3R,4R,5R)-
(3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol,HCl
(3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol hydrochloride
所属类别
有机原料：杂环化合物物理化学性质
沸点317.2±37.0 °C(Predicted)
密度1.279±0.06 g/cm3(Predicted)
储存条件2-8°C(protect from light)
溶解度溶于二甲基亚砜
酸度系数(pKa)14.19±0.60(Predicted)
形态Oil
颜色Colorless to light yellow
常见问题列表
生物活性
Afegostat 是一种药理学伴侣，高亲和力且特异性和可逆地结合内质网 (ER) 中的酸性 β-葡萄糖苷酶 (GCase)。靶点
GCase
体内研究
Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates.