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170846-74-9

中文名称 CHPG
英文名称 CHPG
CAS 170846-74-9
分子式 C8H8ClNO3
分子量 201.61
MOL 文件 170846-74-9.mol
更新日期 2024/08/13 09:29:25
170846-74-9 结构式 170846-74-9 结构式

基本信息

中文别名
化合物 T10809
英文别名
CHPG
(RS)-2-CHLORO-5-HYDROXYPHENYLGLYCINE
α-amino-2-chloro-5-hydroxybenzeneacetic acid
Benzeneacetic acid, α-amino-2-chloro-5-hydroxy-
(RS)-2-chloro-5-hydroxyphenylglycine α-amino-2-chloro-5-hydroxybenzeneacetic acid
α-Amino-2-chloro-5-hydroxybenzeneacetic acid, (RS)-2-Chloro-5-hydroxyphenylglycine

物理化学性质

储存条件2-8°C
溶解度二甲基亚砜:≥10mg/mL
形态固体&_&白色固体
颜色白色

安全数据

危险性符号(GHS)
GHS07
警示词警告
危险性描述H315-H319-H335
危险品标志Xi
危险类别码36/37/38
安全说明26
WGK Germany3

常见问题列表

生物活性
CHPG 是一个选择性的 mGluR5 激动剂,并且通过 TSG-6/NF-κB 途径减弱 BV2 小神经胶质细胞 SO2 诱导的氧化应激和炎症。 CHPG 通过 ERK 和 Akt 途径在体外和体内预防创伤性脑损伤 (TBI)。
靶点

mGlu 5

NF-κB

ERK

Akt

体外研究

CHPG (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO 2 derivatives treatment.
CHPG (0.5 mM; 30 mins ) protects BV2 cells against SO 2 -induced apoptosis.
CHPG (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels.

Cell Viability Assay

Cell Line: BV2 microglial cells
Concentration: 10, 50, 100 and 500 µM
Incubation Time: 24 hours
Result: Increased the cell viability.

Apoptosis Analysis

Cell Line: BV2 microglial cells
Concentration: 0.5 mM
Incubation Time: 30 mins
Result: Protected BV2 cells against SO 2 -induced apoptosis.

Western Blot Analysis

Cell Line: BV2 microglial cells
Concentration: 0.5 mM
Incubation Time: 30 mins
Result: Increased the expression of TSG-6 in both mRNA and protein levels.
体内研究

CHPG (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume.

Animal Model: Adult Sprague-Dawley male rats weighing 280-320 g
Dosage: 250 nM
Administration: Injection; for 7 days
Result: Reduced significantly cerebral lesion volume.
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