174575-17-8
中文名称
(S)-ALPHA-氨基-2'-氯-5-(膦酰基甲基)-[1,1'-联苯]-3-丙酸
英文名称
SDZ 220-581
CAS
174575-17-8
分子式
C16H17ClNO5P
分子量
369.74
MOL 文件
174575-17-8.mol
更新日期
2024/12/03 15:40:31
174575-17-8 结构式
基本信息
中文别名
(S)-ALPHA-氨基-2'-氯-5-(膦酰基甲基)-[1,1'-联苯]-3-丙酸 英文别名
SDZ 220-581(S)-α-Amino-2'-chloro-5-(phosphonomethyl)[1,1'-biphenyl]-3-propanoicacid
alpha-Amino-2'-chloro-5-(phosphonomethyl)(1,1'-biphenyl)-3-propanoic acid
(S)-ALPHA-AMINO-2'-CHLORO-5-(PHOSPHONOMETHYL)[1,1'-BIPHENYL]-3-PROPANOIC ACID
[1,1'-Biphenyl]-3-propanoic acid, α-amino-2'-chloro-5-(phosphonomethyl)-, (αS)-
物理化学性质
沸点613.3±65.0 °C(Predicted)
密度1.478
储存条件Store at RT
溶解度DMSO : 8.57 mg/mL (23.18 mM; Need ultrasonic and warming)
酸度系数(pKa)1.63±0.10(Predicted)
形态粉末
颜色Light yellow to yellow
(S)-ALPHA-氨基-2'-氯-5-(膦酰基甲基)-[1,1'-联苯]-3-丙酸价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-13059 | (S)-ALPHA-氨基-2'-氯-5-(膦酰基甲基)-[1,1'-联苯]-3-丙酸 SDZ 220-581 | 174575-17-8 | 5 mg | 550元 |
| 2025/02/08 | HY-13059 | (S)-ALPHA-氨基-2'-氯-5-(膦酰基甲基)-[1,1'-联苯]-3-丙酸 SDZ 220-581 | 174575-17-8 | 10mM * 1mLin DMSO | 610元 |
| 2025/02/08 | HY-13059 | (S)-ALPHA-氨基-2'-氯-5-(膦酰基甲基)-[1,1'-联苯]-3-丙酸 SDZ 220-581 | 174575-17-8 | 10mg | 1000元 |
常见问题列表
生物活性
SDZ 220-581 是一种口服生物利用度，有效的竞争性的 NMDA 受体拮抗剂，pKi 值为 7.7。靶点
pKi: 7.7 ( NMDA receptor )
体内研究
SDZ 220-581 (3.2-32 mg/kg; oral administration; for 24 hours; male OF-l mice) treatment dose-dependently protects mice against maximal electroshock seizures (MES). The time-course of protection by SDZ 220-581 is characterized by a rapid onset and long duration of action.
| Animal Model: | Male OF-l mice (18-26 g) |
| Dosage: | 3.2 mg/kg, 10 mg/kg, 32 mg/kg |
| Administration: | Oral administration; for 24 hours |
| Result: | Dose-dependently protected mice against maximal electroshock seizures (MES) upon oral administration. |