17466-45-4
中文名称
毒蠅虎蕈鹼
英文名称
PHALLOIDIN
CAS
17466-45-4
分子式
C35H48N8O11S
分子量
788.87
MOL 文件
17466-45-4.mol
更新日期
2024/07/03 16:58:22
17466-45-4 结构式
基本信息
中文别名
毒伞素鬼笔环肽
毒蠅虎蕈鹼
鬼笔环肽 来源于鬼笔鹅膏
英文别名
Nsc523214PHALLOIDIN
phalloidine
PHALLOIDIN, AMANITA PHALLOIDES
PHALLOIDIN FROM AMANITA PHALLOIDES
pto-l-tryptophyl-4,5-dihydroxy-l-leucyl),cyclic(3,6)-sulfide
Cyclo(L-Ala-D-Thr-L-Cys(1)-L-c4Hyp-L-Ala-L-Trp2(1)-4,5'-dihydroxy-L-Leu-)
cyclic(l-alanyl-d-threonyl-l-cysteinyl-cis-4-hydroxy-l-prolyl-l-alanyl-2-merca
Cyclic(L-alanyl-D-threonyl-L-cysteinyl-cis-4-hydroxy-L-prolyl-L-alanyl-2-mercapto-L-tryptophyl-4,5-dihydroxy-L-leucyl), cyclic (3.fwdarw.6)-sulfide
所属类别
生物化工：多肽物理化学性质
熔点280-282°
比旋光度+55.7°(D/20℃)(c=0.5,メタノール)
密度1.1612 (rough estimate)
折射率1.7400 (estimate)
储存条件+2C to +8C
溶解度DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; Water: 0.5 mg/ml (warm)
沸点1370.5±65.0 °C(Predicted)
酸度系数(pKa)13.03±0.70(Predicted)
形态白色结晶固体
颜色针状或结晶状
水溶解性Soluble to 1 mg/ml in water
Merck13,7273
BRN4347460
稳定性稳定的。与强氧化剂不相容。
安全数据
警示词危险
危险性描述H300+H310+H330
危险品标志T+
危险类别码26/27/28
安全说明22-28-36/37-45
危险品运输编号UN 3462 6.1/PG 2
危险品运输编号UN 3462 6.1/PG 2
WGK Germany3
WGK Germany3
RTECS号SE9800000
F18
危险等级6.1(a)
包装类别I
海关编码2934999090
毒性LD50 i.m. in albino mice: 3.3 mg/g (Vogt); LD50 i.p. in mice: 2 mg/kg (Wieland, Wieland)
常见问题列表
生物活性
Phalloidin 是一种蘑菇衍生的毒素，可以与荧光染料结合来标记细胞骨架的 F-肌动蛋白 (λex=495 nm， λem=520 nm)。体外研究
Phalloidin staining will not work with methanol-fixed cells, probably because of the disruption of actin filament integrity, but it will work with cells fixed in 0.2% glutaraldehyde in PBS. For fluorescein isothiocyanate (FITC)-Phalloidin (or rhodamine isothiocyanate [RITC]-Phalloidin), the excitation wavelength maximum will be near 495 nm (or 550 nm) and the emission wavelength maximum will be ~520 nm based on H 2 O at pH 8.0 as the solvent (575 nm with methanol as the solvent). The emission spectrum of fluorescein can depend on the environmental pH and/or ionic strength.