175013-84-0
175013-84-0 结构式
基本信息
中文别名
托那博沙N-[(3S,4S)-6-乙酰基-3,4-二氢-3-羟基-2,2-二甲基-2H-1-苯并吡喃-4-基]-3-氯-4-氟苯甲酰胺
英文别名
SB 22045SB 220453
TONABERSAT
SB 220453
SB220453
Tonabersat [ban, inn]
Tonabersat (SB-220453)
Tonabersat >=98% (HPLC)
SB-220453
SB 220453
SB220453
N-((3S,4S)-6-Acetyl-3-hydroxy-2,2-diMethylchroMan-4-yl)-3-chloro-4-fluorobenzaMide
2H-Benzo(B)pyran-3-ol, 6-acetyl-4-(3-chloro-4-fluorobenzoylamino)-3,4-dihydro-2,2-dimethyl-
所属类别
生物化工:激动剂抑制剂物理化学性质
沸点554.5±50.0 °C(Predicted)
密度1.38
储存条件2-8°C
溶解度溶于二甲基亚砜
酸度系数(pKa)11.86±0.60(Predicted)
形态粉末
颜色白色至米色
旋光性 (optical activity)[α]/D -100 to -110°, c = 1 in methanol
常见问题列表
生物活性
Tonabersat (SB-220453) 是一种 gap-junction 调节剂。Tonabersat Tonabersat 预防中枢神经系统的炎症损伤。靶点
Gap-junction
体外研究
Tonabersat, a novel benzopyran derivative, inhibits cortical spreading depression (CSD) and therefore might be able to inhibit the early migraine mechanisms.
体内研究
Treatment with Tonabersat (10 mg/kg) significantly inhibits progression of metastatic lesions. Addition of NSC 241240 to either agent profoundly inhibits brain metastasis.