176199-48-7
176199-48-7 结构式
基本信息
Eglumetad
Eglumegad
(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid,2-amino-,(1S,2S,5R,6S)-
Bicyclo[3.1.0]hexane-2,6-dicarboxylicacid, 2-aMino-, [1S-(1a,2b,5a,6a)]-
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-18941 | (1S,2S,5R,6S)-2-氨基二环[3.1.0]己烷-2,6-二羧酸 Eglumegad | 176199-48-7 | 5mg | 1500元 |
| 2024/08/19 | HY-18941 | (1S,2S,5R,6S)-2-氨基二环[3.1.0]己烷-2,6-二羧酸 Eglumegad | 176199-48-7 | 10mM * 1mLin Water | 1650元 |
| 2024/08/19 | HY-18941 | (1S,2S,5R,6S)-2-氨基二环[3.1.0]己烷-2,6-二羧酸 Eglumegad | 176199-48-7 | 10mg | 2500元 |
常见问题列表
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mGluR2R 5 nM (IC 50 ) |
mGluR3R 24 nM (IC 50 ) |
Eglumegad (LY354740) down-regulates spots 1014, 1822 (hypoxia up-regulated protein 1), 4513 (an isoform of protein disulfide isomerase 3), 6204, 6312, 7306 (26S proteasome non-ATPase regulatory subunit 7) and protein spots 1013 and 6005 (destrin), and up-regulates spot 6507 (collapsin response mediator protein 1) in mouse cortical neurons.
Eglumegad (LY354740) (15 or 30 mg/kg, i.p.) has no effect on spatial working memory performance in Gria1 −/− or WT mice, and it has no effect on rewarded alternation testing with a short inter-trial interval in Gria1 −/− and WT mice at concentration of 30 mg/kg. Eglumegad (LY354740) (15 or 30 mg/kg, i.p.) reduces spontaneous locomotor activity in wild-type and Gria1 −/− mice. Eglumegad (LY354740) (15 mg/kg, i.p.) dreases novelty-induced hyperlocomotion in naive GluA1-KO and pre-handled GluA1-KO males, but not in females. Eglumegad (LY354740) (15 mg/kg, i.p.) significantly reduces the increased c-Fos expression of GluA1-KO males to the level of WT males, but not in of females. Eglumegad (LY354740) (10 mg/kg, i.p.) attenuates the immobilization stress-induced increase in BDNF mRNA expression in the rat mPFC.