179411-94-0
中文名称
(S)-ALPHA-氨基-2'-氯-5-(膦酰甲基)-[1,1'-联苯]-3-丙酸单铵盐
英文名称
SDZ 220-581 (AMMoniuM salt)
CAS
179411-94-0
分子式
C16H26ClN4O5P
分子量
420.828
MOL 文件
179411-94-0.mol
179411-94-0 结构式
基本信息
中文别名
(S)-ALPHA-氨基-2'-氯-5-(膦酰甲基)-[1,1'-联苯]-3-丙酸单铵盐 英文别名
SDZ 220-581 ammoniumSDZ 220-581 (AMMoniuM salt)
Ammonium (S)-2-amino-3-(2'-chloro-5-(phosphonomethyl)-[1,1'-biphenyl]-3-yl)propanoate
(S)-alpha-Amino-2'-chloro-5-(phosphonomethyl)-[1,1'-biphenyl]-3-propanoic acid monoammonium salt
所属类别
生物化工:激动剂抑制剂常见问题列表
生物活性
SDZ 220-581 Ammonium salt 是一种口服生物利用度,有效的竞争性的 NMDA 受体拮抗剂,pKi 值为 7.7。靶点
pKi: 7.7 ( NMDA receptor )
体内研究
SDZ 220-581 (3.2-32 mg/kg; oral administration; for 24 hours; male OF-l mice) treatment dose-dependently protects mice against maximal electroshock seizures (MES). The time-course of protection by SDZ 220-581 is characterized by a rapid onset and long duration of action.
Animal Model: | Male OF-l mice (18-26 g) |
Dosage: | 3.2 mg/kg, 10 mg/kg, 32 mg/kg |
Administration: | Oral administration; for 24 hours |
Result: | Dose-dependently protected mice against maximal electroshock seizures (MES) upon oral administration. |