1802226-78-3
中文名称
PSB-12379
英文名称
PSB-12379
CAS
1802226-78-3
分子式
C18H23N5O9P2
分子量
515.35
MOL 文件
1802226-78-3.mol
更新日期
2023/03/20 15:41:23
1802226-78-3 结构式
基本信息
中文别名
化合物 T12569 英文别名
PSB-12379Adenosine, N-(phenylmethyl)-, 5'-[hydrogen P-(phosphonomethyl)phosphonate]
物理化学性质
沸点894.2±75.0 °C(Predicted)
密度1.89±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度Water: 5 mg/ml, sonicated
酸度系数(pKa)1.62±0.10(Predicted)
形态固体
颜色White to off-white
常见问题列表
生物活性
PSB-12379 是一种核苷酸类似物，是一种有效的 Ecto-5'-Nucleotidase (CD73) 抑制剂，Kis 值为 9.03 nM (鼠) 和 2.21 nM (人)。靶点
Ki: 9.03 nM (rat), 2.21 nM (human) (Ecto-5’-Nucleotidase)
体外研究
Metabolism : Only a small percentage (<23%) of PSB-12379 (10g) is metabolized under the applied conditions, while >77% of the compounds are recovered unchanged after a long incubation for 8 h. PSB-12379 (10g) is somewhat less stable, and 56% are metabolized within 8 h. Hydrolytic cleavage of the glycosidic bond, which is a typical phase I reaction of nucleosides and nucleotides, was observed as the main reaction.