1802997-81-4
中文名称
SEC
英文名称
1H-Pyrazole-5-carboxylic acid, 1-[(2S)-3-(4-chlorophenoxy)-2-hydroxypropyl]-3-(4-methoxyphenyl)-, ethyl ester
CAS
1802997-81-4
分子式
C22H23ClN2O5
分子量
430.88
MOL 文件
1802997-81-4.mol
1802997-81-4 结构式
基本信息
中文别名
金黄色葡萄球菌肠毒素C(SEC)ELISA试剂盒 英文别名
SEC1H-Pyrazole-5-carboxylic acid, 1-[(2S)-3-(4-chlorophenoxy)-2-hydroxypropyl]-3-(4-methoxyphenyl)-, ethyl ester
物理化学性质
沸点627.7±55.0 °C(Predicted)
密度1.27±0.1 g/cm3(Predicted)
酸度系数(pKa)13.31±0.20(Predicted)
形态Oil
颜色Light yellow to yellow
SEC价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-125355 | SEC | 1802997-81-4 | 5mg | 3000元 |
| 2024/04/30 | HY-125355 | SEC | 1802997-81-4 | 10mM * 1mLin DMSO | 3300元 |
| 2024/04/30 | HY-125355 | SEC | 1802997-81-4 | 10mg | 5000元 |
常见问题列表
生物活性
SEC 通过 AMPK/mTORC1/STAT3 信号通路诱导 ANXA7 GTPase 的激活。SEC 选择性的促进癌细胞的凋亡，诱导 ITGB4 核转位，表达高水平 ITGB4。体外研究
SEC (20 µM) inhibits the cell migration of HEK 293T RKIP
−/−
cells and PC3 prostate cancer cells.
SEC (20 µM) significantly increases AMPK phosphorylation in PC3 cells, which is inverted by ANXA7 GTPase specific inhibitor ABO, indicating that activated ANXA7 with enhanced phosphorylation level promotes AMPK phosphorylation (
cell selectively
).
Cell Viability Assay
| Cell Line: | HEK293T RKIP −/− cells. [1] |
| Concentration: | 20 µM. |
| Incubation Time: | 24 h. |
| Result: | Suppressed HEK293T RKIP −/− cell migration while had no effect on HEK293T RKIP +/+ cells. |
体内研究
SEC (3 mg/kg/day or 18 mg/kg/day) suppresses metastasis in PC-3M-Luc orthotopic implantation nude mice model.
| Animal Model: |
Luciferase-labeled PC-3M-Luc cells (2×10
6
per 50 µL sterile HBSS
−/−
) are orthotopically inoculated into the prostates of 8-week-old nude mice.
|
| Dosage: | 3 mg/kg/day or 18 mg/kg/day. |
| Administration: | IP daily for 3 weeks. |
| Result: |
Suppressed the lymph node metastatic capacities of PC-3M-Luc cells in the nude mice model.
Decreased the mRNA level of CCL2 , APLN and IL6ST in implanted tumors. Did not affect the body weight of the mice. |