1808094-07-6
中文名称
1808094-07-6
英文名称
PF-06471553
CAS
1808094-07-6
分子式
C23H25N5O4S
分子量
467.54
MOL 文件
1808094-07-6.mol
1808094-07-6 结构式
物理化学性质
沸点728.7±70.0 °C(Predicted)
密度1.46±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : ≥ 150 mg/mL (320.83 mM)
酸度系数(pKa)6.75±0.20(Predicted)
形态Solid
颜色White to off-white
应用领域
用途一
PF-06471553 is a potent and selective Monoacylglycerol acyltransferase 3 (MGAT3) inhibitor. PF-06471553 selectively inhibits MGAT3 with high in vitro potency and cell efficacy. In the presence of a combination of diacylglycerol acyltransferases 1 and 2 (DGAT1 and DGAT2) inhibitors, an oral administration of PF-06471553 exhibited inhibition of the incorporation of deuterium-labeled glycerol into TAG in mouse model. Inhibition of triacylglycerol (TAG) biosynthetic enzymes has been suggested as a promising strategy to treat insulin resistance, diabetes, dyslipidemia, and hepatic steatosis.