1810734-44-1

英文名称 Benzenesulfonamide, N-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]-N-methyl-4-(trifluoromethoxy)-

CAS 1810734-44-1

分子式 C25H24ClF3N2O3S

分子量 524.98

MOL 文件 1810734-44-1.mol

更新日期 2023/03/20 15:41:21

1810734-44-1 结构式

基本信息物理化学性质 Benzenesulfonamide, N-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]-N-methyl-4-(trifluoromethoxy)-价格(试剂级) 常见问题列表

基本信息

英文别名

TRC-766
Benzenesulfonamide, N-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]-N-methyl-4-(trifluoromethoxy)-

物理化学性质

沸点597.0±60.0 °C(Predicted)

密度1.341±0.06 g/cm3(Predicted)

酸度系数(pKa)0.83±0.20(Predicted)

形态Solid

颜色White to off-white

常见问题列表

生物活性

TRC-766 是一种 RTC-5 (TRC-382) 的阴性对照。TRC-766 可结合蛋白磷酸酶 2A (PP2A)，但不激活磷酸酶。

体外研究

As a pharmacologic control, the cells are treated with increasing doses of TRC-766, which is structurally similar to PP2A (SMAP) but biologically inactive. TRC-766 lacks a key N-H sulfonamide hydrogen bond donor. While TRC-766 still binds PP2A, it does not activate the phosphatase and therefore it was postulated to not affect cell viability.