18201-65-5

中文名称 DICHLOROPHENYL-ABA

英文名称 DICHLOROPHENYL-ABA

CAS 18201-65-5

分子式 C13H9Cl2NO2

分子量 282.12

MOL 文件 18201-65-5.mol

更新日期 2024/09/09 14:27:12

18201-65-5 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

英文别名

benzoic acid, 2-[(3,5-dichlorophenyl)amino]-

物理化学性质

熔点245 °C

沸点420.8±45.0 °C(Predicted)

密度1.470±0.06 g/cm3(Predicted)

储存条件2-8°C

溶解度DMSO: ~18 mg/mL at ~60 °C

酸度系数(pKa)3.62±0.36(Predicted)

形态solid

颜色white

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H315-H319-H335

防范说明P261-P305+P351+P338

危险品标志Xi

危险类别码36/37/38

安全说明26-36

WGK Germany3

常见问题列表

生物活性

Dichlorophenyl-ABA 是转甲状腺素蛋白 (TTR) 淀粉样蛋白原纤维形成的抑制剂，可抑制表达 TTR L55P 的细胞中 80％以上的聚集体形成。

靶点

Transthyretin (TTR) amyloid fibril formation

体外研究

Dichlorophenyl-ABA (DCPA) is able to prevent L55P aggregate formation in the conditioned medium. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole, indicating that the Y78F mutant may not be as sensitive to this drug as TTR L55P and V30M are.
Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP) but need to undergo further stages of drug development to overcome their toxicity.