1820684-31-8
1820684-31-8 结构式
基本信息
中文别名
化合物 T15943 英文别名
M-443M-443 (M443
Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-2-pyrimidinyl]amino]-
物理化学性质
密度1.34±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : 55 mg/mL (93.28 mM)
酸度系数(pKa)12.95±0.70(Predicted)
形态Solid
颜色Light yellow to yellow
应用领域
用途一
M443 is a specific small molecule inhibitor of MRK. M443 strongly radiosensitizes UW228 medulloblastoma cells as well as UI226 patient-derived primary cells, whereas it does not affect the response to radiation of normal brain cells. M443 also inhibits radiation-induced activation of both p38 and Chk2, two proteins that act downstream of MRK and are involved in DNA damage-induced cell-cycle arrest.