1821370-28-8
中文名称
MitoPQ
英文名称
MitoPQ
CAS
1821370-28-8
分子式
C39H46IN2P+2
分子量
700.69
MOL 文件
1821370-28-8.mol
更新日期
2024/05/27 22:24:16
1821370-28-8 结构式
物理化学性质
储存条件-20°C储存
溶解度DMF: 25 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 1 mg/ml; Ethanol: 0.33 mg/ml
形态结晶固体
颜色Brown to reddish brown
应用领域
用途一
MitoPQ, also known as MitoParaquat, is a redox cycler. MitoParaquat (MitoPQ) that comprises a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat. MitoPQ accumulates selectively in the mitochondrial matrix driven by the membrane potential. Within the matrix, MitoPQ produces superoxide by redox cycling at the flavin site of complex I, selectively increasing superoxide production within mitochondria. MitoPQ increased mitochondrial superoxide in isolated mitochondria and cells in culture ~a thousand-fold more effectively than untargeted paraquat. MitoPQ was also more toxic than paraquat in the isolated perfused heart and in Drosophila in vivo. MitoPQ enables the selective generation of superoxide within mitochondria and is a useful tool to investigate the many roles of mitochondrial superoxide in pathology and redox signaling in cells and in vivo.