182369-28-4
![182369-28-4 结构式](/CAS/20200611/GIF/182369-28-4.gif)
基本信息
1,3-Cyclohexanediol, 5-[(2E)-[(1S,3aS,7aS)-1-[(1R)-1-[(3-ethyl-3-hydroxypentyl)oxy]ethyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)- (9CI)
物理化学性质
常见问题列表
IC50: 0.82 nM
CB1151 (0-100 nM; 5 days) inhibits MCF-7 cells growth, this cell proliferation is accessed by [ 3 H]-thymidine incorporation, exhibits an IC 50 value of 0.82 nM. CB1151 (0-100 nM; 40 hours) exhibits activation of the IP9-type VD response element with a EC 50 of 1.2 nM, the activation of IP9-type VD response elements shows a good correlation with inhibition of proliferation than the activation of DR3-type elements (EC 50 =3.2nM) in MCF-7 cells transfected with the CAT reporter. CB1151 shows a functional dissociation constant (K df ) value of 3.6 nM. The ligand concentration that provides 50% of protease-resistant VDR fragment is defined by K df , this is different from that of the traditional dissociation constant (K d ).
Cell Proliferation Assay
Cell Line: | MCF-7 cell |
Concentration: | 0 nM; 0.1nM; 0.5nM; 0.8nM; 1nM; 5nM; 10 nM |
Incubation Time: | 5 days |
Result: | Inhibits MCF-7 cells growth. |