1825355-56-3
1825355-56-3 结构式
基本信息
4(3H)-Pyrimidinone, 2-[(3S)-1-[[1-(2-pyrimidinyl)-1H-imidazol-4-yl]methyl]-3-piperidinyl]-6-(2-thienyl)-
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-19488A | 1825355-56-3 Ribocil-C | 1825355-56-3 | 5mg | 900元 |
| 2024/11/08 | HY-19488A | 1825355-56-3 Ribocil-C | 1825355-56-3 | 10mM * 1mLin DMSO | 990元 |
| 2024/11/08 | HY-19488A | 1825355-56-3 Ribocil-C | 1825355-56-3 | 10mg | 1600元 |
常见问题列表
Bacterial riboflavin riboswitches
Ribocil-C is a highly selective inhibitor of the flavin mononucleotide (FMN) riboswitch that controls expression of de novo riboflavin (RF, vitamin B2) biosynthesis in Escherichia coli . Ribocil-C specifically inhibits dual FMN riboswitches, separately controlling RF biosynthesis and uptake processes essential for Staphylococcus aureus growth and pathogenesis. Ribocil-C is a small-molecule synthetic mimic of FMN that binds the FMN riboswitch of multiple GN bacteria, including Escherichia coli , Pseudomonas aeruginosa , and Acinetobacter baumannii , to inhibit ribB expression, RF synthesis, and consequently arrest bacterial growth.
Higher dose Ribocil-C treatment groups (60 and 120 mg kg21 ribocil-C) demonstrate a dose-dependent reduction in bacterial burden of 1.87 and 3.29 log 10 [CFU per g spleen] reduction respectively versus shamtreated mice, without mortality or gross effects of toxicity observed.