186268-78-0
中文名称
1-(1,2-二氧代-3,3-二甲基戊基)-2(S)-2吡咯烷甲酸
英文名称
(2S)-1-(1',2'-DIOXO-3',3'-DIMETHYL-PENTYL)-2-PYRROLIDINE-CARBOXYLIC ACID
CAS
186268-78-0
分子式
C12H19NO4
分子量
241.28
MOL 文件
186268-78-0.mol
更新日期
2023/03/20 15:41:29
186268-78-0 结构式
基本信息
中文别名
1-(1,2-二氧代-3,3-二甲基戊基)-2(S)-2吡咯烷甲酸(2S)-1-(1,2-二氧代-3,3-二甲基戊基)-2-吡咯烷甲酸
英文别名
GPI-1485GPI-1485 L
L-Proline, 1-(3,3-dimethyl-1,2-dioxopentyl)-
(2S)-1-(3,3-Dimethyl-2-oxopentanoyl)-pyrrolidine-2-carboxylic acid
(2S)-1-(1',2'-DIOXO-3',3'-DIMETHYL-PENTYL)-2-PYRROLIDINE-CARBOXYLIC ACID
物理化学性质
沸点386.2±52.0 °C(Predicted)
密度1.188±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)3.25±0.20(Predicted)
形态Solid
颜色White to light yellow
常见问题列表
生物活性
GPI-1485 (GM1485) 是一种免疫抑制剂的特异性亲免蛋白配体，促进中风后的神经功能改善和神经再生。体外研究
GPI-1485 (GM1485; 100 μM) induces cellular reprogramming and neural cell induction in normal human dermal fibroblasts (NHDF).
Cell Viability Assay
| Cell Line: | Normal human dermal fibroblasts (NHDF) [1] |
| Concentration: | 100 μM |
| Incubation Time: | |
| Result: | Induced cellular reprogramming and neural cell induction. |
体内研究
GPI-1485 (GM1485; 5 mg/kg; intraperitoneal injection; 6-week period of daily) improves long-term neurological recovery in rats.
| Animal Model: | Adult male Wistar rats, weighing 250-300 g |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection; daily; for a total of 42 days |
| Result: | Administration improved neurological function and is consistent with an upregulation of endogenous neurogenesis following stroke in rats. |