1863905-38-7
1863905-38-7 结构式
常见问题列表
生物活性
PF-06737007 是一种有效的 pan-Trk 抑制剂，抑制 TrkA，TrkB 和 TrkC 细胞，IC50 分别为 7.7 nM，15 nM 和 3.9 nM。具有抗痛觉过敏作用。靶点
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TrkA 7.7 nM (IC 50 , in cell-based assays) |
TrkB 15 nM (IC 50 , in cell-based assays) |
TrkC 3.9 nM (IC 50 , in cell-based assays) |
体外研究
PF-06737007 (Compound 13b) exhibits superb Trk selectivity with >95% inhibition of TrkA with no other kinase being inhibited by >40% at 1 μM.