187269-40-5

中文名称 Bimosiamose

英文名称 Bimosiamose

CAS 187269-40-5

分子式 C46H54O16

分子量 862.92

MOL 文件 187269-40-5.mol

187269-40-5 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

中文别名

比莫西糖

英文别名

TBC-1269
Bimosiamose
[1,1'-Biphenyl]-3-acetic acid, 3',3'''-(1,6-hexanediyl)bis[6'-(α-D-mannopyranosyloxy)-

物理化学性质

熔点115-117°

沸点1051.0±65.0 °C(Predicted)

密度1.417±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMSO:100.0(Max Conc. mg/mL);115.89(Max Conc. mM)
0.1 M NaOH:25.0(Max Conc. mg/mL);28.97(Max Conc. mM)

酸度系数(pKa)3.95±0.10(Predicted)

形态结晶固体

颜色White to off-white

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H302-H315-H319-H335

防范说明P261-P280-P301+P312-P302+P352-P305+P351+P338

常见问题列表

生物活性

Bimosiamose (TBC-1269) 是一种非寡糖泛-selectin 拮抗剂，对 E-selectin，P-selectin 和 L-selectin 的 IC50 分别为 88 μM，20 μM 和 86μM。Bimosiamose 具有抗炎作用。

靶点

IC50: 88 μM (E-selectin), 20 μM (P-selectin), 86 μM (L-selectin)

体外研究

Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils.

体内研究

Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved.

Animal Model:	Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R)
Dosage:	25 mg/kg
Administration:	Intravenous injection
Result:	Showed a significant increase in survival compared with controls.