187269-60-9

中文名称 BIMOSIAMOSE DISODIUM

CAS 187269-60-9

分子式 C46H52Na2O16

分子量 906.875

MOL 文件 187269-60-9.mol

187269-60-9 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

比莫西糖二钠盐

英文别名

TBC-1269Z
Bimosiamose disodium

物理化学性质

熔点243-245°

常见问题列表

生物活性

Bimosiamose disodium (TBC-1269Z) 是一种非寡糖泛-selectin 抑制剂，对 E-selectin，P-selectin 和 L-selectin 的 IC50 分别为 88 μM，20 μM 和 86μM。Bimosiamose disodium 具有抗炎作用。

靶点

IC50: 88 μM (E-selectin), 20 μM (P-selectin), and 86 μM (L-selectin)

体外研究

Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils.

体内研究

Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved.

Animal Model:	Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R)
Dosage:	25 mg/kg
Administration:	Intravenous injection
Result:	Showed a significant increase in survival compared with controls.