1884420-36-3
中文名称
Terlipressin Diacetate Salt
CAS
1884420-36-3
1884420-36-3 结构式
常见问题列表
生物活性
Terlipressin acetate 是一种具有血管活性的加压素类似物，也是一种高度选择性的加压素 V1 受体激动剂，可减少内脏血流量和门脉压力并控制急性静脉曲张破裂出血。Terlipressin acetate 具有抗炎和抗氧化作用，可用于肝肾综合征和耐去甲肾上腺素的败血性休克的研究。靶点
Vasopressin V1 receptor
体外研究
Terlipressin (25 nM; 24-72 hours; IEC-6 cells) treatment significantly improves cell viability, proliferation and apoptosis in IEC-6 cells.
Terlipressin inhibits the secretion of TNF-α and 15-F2t-isoprostane from IEC-6 cells following oxygen and glucose deprivation/re-oxygenation (OGD/R). Terlipressin administration following OGD attenuates OGD/R-induced cell damage via the PI3K signaling pathway.
Cell Proliferation Assay
| Cell Line: | IEC-6 cells induced by oxygen and glucose deprivation/re-oxygenation (OGD/R) |
| Concentration: | 25 nM |
| Incubation Time: | 24 hours, 48 hours, 72 hours |
| Result: | Significantly increased the proliferation of IEC-6 cells. |
体内研究
Using a mouse nonlethal hepatic ischemia-reperfusion (IR) model, Terlipressin administration significantly ameliorates IR-induced liver apoptosis, necrosis and inflammation.