基本信息
中文别名
芒雷素 英文别名
ARISTEROMYCINCycloadenosine
3-Aristeromycin
4'-O-Carbaadenosine
Carbocyclic adenosine
9-[2,3-DIHYDROXY-4-(HYDROXYMETHYL)CYCLOPENTYL]ADENINE
(1r,2s,3r,5r)-3-(6-amino-9h-purin-9-yl)-5-(hydroxymethyl)-1,2-cyclopentanedi
1,2-cyclopentanediol,3-(6-amino-9h-purin-9-yl)-5-(hydroxymethyl)-,(1r,2s,3r,5
(1R,2S,3R,5R)-3-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol
(1R,2S,3R,5R)-3-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)-1,2-cyclopentanediol
常见问题列表
生物活性
Aristeromycin，腺苷类似物，是一种抗生素和有效的S-腺苷同型半胱氨酸水解酶 (AHCY) 抑制剂。靶点
S-adenosylhomocysteine hydrolase
体外研究
The IC
50
value of Aristeromycin against AHCY is 38.5 nM at 50 μM S-adenosylhomocysteine (SAH) (approximately equal to the Km: 48 μM), but 271 nM at 1000 µM SAH (20× Km). With 60 min of preincubation, the mean IC
50
value of Aristeromycin at 50 μM SAH is 12.7 nM.
Aristeromycin has IC
50
values of 3.2 μM for LNCaP-FGC cell growth and 0.88 μM for LNCaP-hr cell growth.
At least in part, Aristeromycin can regulate oncogenic EZH2 expression by inducing miR-26a.