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192725-39-6

中文名称 洛匹那韦代谢物M1
CAS 192725-39-6
分子式 C37H46N4O6
分子量 642.792
MOL 文件 192725-39-6.mol
192725-39-6 结构式 192725-39-6 结构式

基本信息

中文别名
洛匹那韦代谢物M1
英文别名
4-Oxo-ABT-378
Lopinavir Impurity 22
Lopinavir IP Impurity E
Lopinavir Metabolite M-1
(aS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2,4-dioxo-1(2H)-Pyrimidineacetami-de
(aS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2,4-dioxo-1(2H)-Pyrimidineacetami- d
(aS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2,4-dioxo-1(2H)-Pyrimidineacetami- de
(αS)-N-[(1S,3S,4S)-4-[[(2,6-DiMethylphenoxy)acetyl]aMino]-3-hydroxy-5-phenyl-1-(phenylMethyl)pentyl]tetrahydro-α-(1-Methylethyl)-2,4-dioxo-1(2H)-pyriMidineacetaMi- de

物理化学性质

熔点106-108°C
储存条件-20°C冷冻

常见问题列表

生物活性
Lopinavir Metabolite M-1 是 Lopinavir 的活性代谢产物,以 0.7 pM 的 Ki 值抑制 HIV 蛋白酶。Lopinavir Metabolite M-1 在体外具有抗病毒活性。
靶点

IC50: 0.7 pM (HIV Protease)

体外研究

Lopinavir Metabolite M-1 has antiviral activities in MT-4 cells, with an EC 50 of 1.413 μM.

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