193620-69-8
中文名称
3-(双(4-甲氧基苯基)亚甲基)吲哚啉-2-酮
英文名称
TAS-301
CAS
193620-69-8
分子式
C23H19NO3
分子量
357.4
MOL 文件
193620-69-8.mol
更新日期
2024/07/21 13:45:54
193620-69-8 结构式
基本信息
中文别名
TAS-301游离态3-[二(4-甲氧基苯基)亚甲基]-1,3-二氢-2H-吲哚-2-酮
英文别名
CS-1543TAS 301.TAS301
TAS-301
TAS 301.TAS301
3-[bis(4-methoxyphenyl)methylidene]-1H-indol-2-one
3-[Bis(4-methoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one
2H-Indol-2-one,3-[bis(4-methoxyphenyl)methylene]-1,3-dihydro-
3-(双(4-甲氧基苯基)亚甲基)吲哚啉-2-酮价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/16 | S6424 | 3-(双(4-甲氧基苯基)亚甲基)吲哚啉-2-酮 TAS-301 | 193620-69-8 | 5mg | 877.31元 |
| 2023/03/20 | S6424 | 3-(双(4-甲氧基苯基)亚甲基)吲哚啉-2-酮 TAS-301 | 193620-69-8 | 25mg | 2596.51元 |
常见问题列表
生物活性
TAS-301是平滑肌细胞迁移和增殖的抑制剂，在大鼠颈动脉球囊损伤后抑制内膜增厚。TAS-301 可抑制PDGF诱导的 PKC 激活。靶点
| Target | Value |
|
PKC
() |
体外研究
TAS-301 (1-10 μM) concentration-dependently inhibits PKC activation and Ca 2+ influx, induced by PDGF, with 62.7% inhibition on PKC activation at 10 μM, and reduces PMA-induced AP-1, with 38% and 67.6% inhibition at 3 and 10 μM, respectively. TAS-301 (0.3-3 μM) dose-dependently reduces the migration of cells induced by growth factors (PDGF-BB, IGF-1,HB-EGF). TAS-301 (1-10 μM) also decreases bFGF-induced BrdU incorporation, especially at 3 and 10 μM.
体内研究
TAS-301 (3-100 mg/kg, p.o.) dose-dependently reduces the neointimal thickening and I/M ratio and decreases the level of intimal cells in rats 14 days after balloon injury.